Figure 9.2. Pyrvinium, a cyanine dye formulated as the almost insoluble pamoate, was formerly used to treat pinworm infections. It is hazardous, so the first aid measures and others should be known. Alibaba.com offers 891 antimony potassium tartrate products. Antimony potassium tartrate, also known as potassium antimonyl tartrate, potassium antimontarterate, or emetic tartar,  has the formula K 2 Sb 2 (C 4 H 2 O 6) 2 and is the double salt of potassium and antimony of tartaric acid.The compound has long been known as a powerful emetic, and was used in the treatment of schistosomiasis and leishmaniasis.. National Oceanic and Atmospheric Administration. Hợp chất này từ lâu đã được biết đến như một chất xúc tác mạnh mẽ, tan trong glyxerol nhưng không tan trong cồn. The exact mechanism of its action in the worm is unknown, but it is thought to produce paralysis of the adult worm, resulting in its detachment from the vein wall. dopamine. A 70-year-old 60 kg French lady with cutaneous mediterranian leischmaniasis attracted during a holiday in Spain was treated with i.m. When he arrived home his wife gave him a glass of lemonade in which she had dissolved a powder she believed would prevent him from drinking alcohol. D-Antimony potassium tartrate. High purity, submicron and nanopowder forms may be considered. Antimony potassium tartrate solid is a colorless crystalline solid or a white powder. Potassium Antimony Tartrate, Trihydrate … ANTIMONIUM TART. She was transferred to respirator in the intensive care unit with acute dyspnea but died 5 day after admission due to severe irreversible circulatory collapse. Antimony potassium tartrate (APT) at doses up to 168 mg ATP (or 30.63 mg antimony)/kg body weight (bw)/day (mg/kg/day) was administered in drinking water to juvenile male and female rats continuously for 14 days, followed by 1 day of observation . injections of glucamtine (meglumine antimonite) up to 4 ampoules of 425 mg Sb per day, total 50–52 ampoules over 2 weeks, slightly more than the recommended dose of 20 mg/kg per day for 2 weeks. Sunagawa (1981) gave rats 0.5-2% antimony and antimony trioxide in the diet. The quality of the drug should be strictly assured as the literature describes that substandard drugs may cause fatal cardiotoxicity.99,100, Carolyn A. Tylenda, ... Bruce A. Fowler, in Handbook on the Toxicology of Metals (Fourth Edition), 2015. Praizquantel, however, is now almost exclusively used in the treatment of schistosomiasis. It finds application in medicine as an expectorant and a nauseant. It is soluble in water. There is, however, a tendency for antimony to produce earlier more profuse vomiting, less systemic absorption, more rapid excretion, and thus a shorter course without severe neurological sequelae. Human poisonings are rare. It also can be called Antimony potassium tartrate trihydrate ; and Antimonate (2-), bis (mu- (2,3-dihydroxybutanedioato (4-)-O1,O2:O3,O4))di-, dipotassium, trihydrate, stereoisomer. Antimony potassium tartrate is a schistosomicide possibly useful against other parasites. Sampaio  evaluated three dose regimens of glucantime: (a) 28 mg/kg for 10 days, repeated thrice 15 days apart, (b) 10 mg/kg daily for 30 days, and (c) 20 mg/kg daily for 30 days and observed the last dose schedule to be the most effective in curing mucocutaneous leishmaniasis in humans. Fatty degeneration in the liver, but no effects in the kidney, was recorded in an inhalation exposure study on guinea pigs (Dernehl et al., 1945). Potassium tartrate is produced by the reaction of tartaric acid with potassium sodium tartrate (rochelle salt), and potassium sulfate, followed by filtration, purification, precipitation and drying. Zijlstra et al. It is soluble in water. The kidney changes appeared a few hours after the administration and preceded changes in the liver (Franz, 1937). EC Index Number 234-293-3 After 24 weeks, the most exposed animals had elevated serum levels of a liver enzyme, Aspartate aminotransferase (GOT). China; millions of schistosomiasis patients were given this drug. BAL is effective in treating poisoning by antimony potassium tartrate, but this is not true of all organic antimony compounds. 23 potassium antimony tartrate products are offered for sale by suppliers on Alibaba.com A wide variety of potassium antimony tartrate options are available to you, There are 15 suppliers who sells potassium antimony tartrate on Alibaba.com, mainly located in Asia. Harmful if swallowed. followed by oral 100 mg DMPS 3 times per day for 10 days followed by 3 times 50 mg per day for another 10 days.  found that the drug may be given at a dose of 20 mg/kg daily for 85 days to achieve successful treatment of leishmaniasis. It is used in making insecticides or pesticides. By comparing the cytotoxicity of PAT in various nonsmall … Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This section provides a listing of alternate names for this chemical, It finds application in medicine as an expectorant and a nauseant. In one severe acute oral poisoning, a three-year-old girl drank nearly 50 mL of a sweet tasting liquid against ants containing 2.3 g tartar emetic, several times the lethal dose for children. duodenale and has no useful effect against other intestinal worms. The dose in cough remedies or expectorants varies from 1 to 8 mg repeated two or three times daily. Tartar emetic (10) and stibophen (16) have been used to treat Trypanosoma congolense and T. vivax infections in cattle and T. evansi in camel. 9.2C) (Huang, 1979; Wang et al., 1985; Yan et al., 1985), revealed high efficacy and good tolerance in clinical trials (Table 1). There is increasing concern about the development of resistance to praziquantel, but fortunately it has not been materialized. Fatty degeneration occurred in the convoluted tubules of the kidney and the liver after a single administration of 60 mg antimony potassium tartrate solution to rabbits. Wang B, Yu W, Guo J, Jiang X, Lu W, Liu M, Pang X J Pharmacol Exp Ther 2015 Jan;352(1):129-38. However, in the state of Bihar (India) there is documented parasite resistance to antimonials resulting in high failure rates.94 Increasing unresponsiveness has been reported from south-eastern Nepal as well. Trioxide in the victim 's eyes without specific instructions from a physician during a... 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