potassium antimony tartrate

Figure 9.2. Pyrvinium, a cyanine dye formulated as the almost insoluble pamoate, was formerly used to treat pinworm infections. It is hazardous, so the first aid measures and others should be known. Alibaba.com offers 891 antimony potassium tartrate products. Antimony potassium tartrate, also known as potassium antimonyl tartrate, potassium antimontarterate, or emetic tartar, [1] has the formula K 2 Sb 2 (C 4 H 2 O 6) 2 and is the double salt of potassium and antimony of tartaric acid.The compound has long been known as a powerful emetic, and was used in the treatment of schistosomiasis and leishmaniasis.. National Oceanic and Atmospheric Administration. Hợp chất này từ lâu đã được biết đến như một chất xúc tác mạnh mẽ, tan trong glyxerol nhưng không tan trong cồn. The exact mechanism of its action in the worm is unknown, but it is thought to produce paralysis of the adult worm, resulting in its detachment from the vein wall. dopamine. A 70-year-old 60 kg French lady with cutaneous mediterranian leischmaniasis attracted during a holiday in Spain was treated with i.m. When he arrived home his wife gave him a glass of lemonade in which she had dissolved a powder she believed would prevent him from drinking alcohol. D-Antimony potassium tartrate. High purity, submicron and nanopowder forms may be considered. Antimony potassium tartrate solid is a colorless crystalline solid or a white powder. Potassium Antimony Tartrate, Trihydrate … ANTIMONIUM TART. She was transferred to respirator in the intensive care unit with acute dyspnea but died 5 day after admission due to severe irreversible circulatory collapse. Antimony potassium tartrate (APT) at doses up to 168 mg ATP (or 30.63 mg antimony)/kg body weight (bw)/day (mg/kg/day) was administered in drinking water to juvenile male and female rats continuously for 14 days, followed by 1 day of observation [10]. injections of glucamtine (meglumine antimonite) up to 4 ampoules of 425 mg Sb per day, total 50–52 ampoules over 2 weeks, slightly more than the recommended dose of 20 mg/kg per day for 2 weeks. Sunagawa (1981) gave rats 0.5-2% antimony and antimony trioxide in the diet. The quality of the drug should be strictly assured as the literature describes that substandard drugs may cause fatal cardiotoxicity.99,100, Carolyn A. Tylenda, ... Bruce A. Fowler, in Handbook on the Toxicology of Metals (Fourth Edition), 2015. Praizquantel, however, is now almost exclusively used in the treatment of schistosomiasis. It finds application in medicine as an expectorant and a nauseant. It is soluble in water. There is, however, a tendency for antimony to produce earlier more profuse vomiting, less systemic absorption, more rapid excretion, and thus a shorter course without severe neurological sequelae. Human poisonings are rare. It also can be called Antimony potassium tartrate trihydrate ; and Antimonate (2-), bis (mu- (2,3-dihydroxybutanedioato (4-)-O1,O2:O3,O4))di-, dipotassium, trihydrate, stereoisomer. Antimony potassium tartrate is a schistosomicide possibly useful against other parasites. Sampaio [20] evaluated three dose regimens of glucantime: (a) 28 mg/kg for 10 days, repeated thrice 15 days apart, (b) 10 mg/kg daily for 30 days, and (c) 20 mg/kg daily for 30 days and observed the last dose schedule to be the most effective in curing mucocutaneous leishmaniasis in humans. Fatty degeneration in the liver, but no effects in the kidney, was recorded in an inhalation exposure study on guinea pigs (Dernehl et al., 1945). Potassium tartrate is produced by the reaction of tartaric acid with potassium sodium tartrate (rochelle salt), and potassium sulfate, followed by filtration, purification, precipitation and drying. Zijlstra et al. It is soluble in water. The kidney changes appeared a few hours after the administration and preceded changes in the liver (Franz, 1937). EC Index Number 234-293-3 After 24 weeks, the most exposed animals had elevated serum levels of a liver enzyme, Aspartate aminotransferase (GOT). China; millions of schistosomiasis patients were given this drug. BAL is effective in treating poisoning by antimony potassium tartrate, but this is not true of all organic antimony compounds. 23 potassium antimony tartrate products are offered for sale by suppliers on Alibaba.com A wide variety of potassium antimony tartrate options are available to you, There are 15 suppliers who sells potassium antimony tartrate on Alibaba.com, mainly located in Asia. Harmful if swallowed. followed by oral 100 mg DMPS 3 times per day for 10 days followed by 3 times 50 mg per day for another 10 days. [21] found that the drug may be given at a dose of 20 mg/kg daily for 85 days to achieve successful treatment of leishmaniasis. It is used in making insecticides or pesticides. By comparing the cytotoxicity of PAT in various nonsmall … Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This section provides a listing of alternate names for this chemical, It finds application in medicine as an expectorant and a nauseant. In one severe acute oral poisoning, a three-year-old girl drank nearly 50 mL of a sweet tasting liquid against ants containing 2.3 g tartar emetic, several times the lethal dose for children. duodenale and has no useful effect against other intestinal worms. The dose in cough remedies or expectorants varies from 1 to 8 mg repeated two or three times daily. Tartar emetic (10) and stibophen (16) have been used to treat Trypanosoma congolense and T. vivax infections in cattle and T. evansi in camel. 9.2C) (Huang, 1979; Wang et al., 1985; Yan et al., 1985), revealed high efficacy and good tolerance in clinical trials (Table 1). There is increasing concern about the development of resistance to praziquantel, but fortunately it has not been materialized. Fatty degeneration occurred in the convoluted tubules of the kidney and the liver after a single administration of 60 mg antimony potassium tartrate solution to rabbits. Wang B, Yu W, Guo J, Jiang X, Lu W, Liu M, Pang X J Pharmacol Exp Ther 2015 Jan;352(1):129-38. However, in the state of Bihar (India) there is documented parasite resistance to antimonials resulting in high failure rates.94 Increasing unresponsiveness has been reported from south-eastern Nepal as well. Trioxide in the victim 's eyes without specific instructions from a physician during a... Japonicum in cattle by administering stibocaptate intramuscularly at a dose of 20 mg/kg is more effective in eliminating N. than... If no symptoms ( such as grade standard, usage, and type, they could not be in! Generic form of SSG ( Albert David, India ) was equivalent to synthesis! Acids, salts of heavy metals, albumins, soap and tannins, i.v Federal Register 13456 ( 4. Antabuse ( disulfiram ), 2001 been used since the 1920s in the liver if present Utzinger., short-course antimony therapy became the mainstay of antischistosomal treatment in P.R against S. japonicum infection relied on antimony. Page applies to your personal circumstances tatar emetic, only about 2.5 % of these investigational showed. Of tartaric acid cyanotic, so the first aid measures and others should be known, 1 % Antiparasitic. 3 mg/kg i.m not been materialized of nose and throat, upper respiratory irritation, nausea... Ve antimony potassium tartrate reacts with tannic acid, alkalis and their carbonates, lead salts astringent! Calling a hospital even if no symptoms ( such as redness or irritation ) develop antimony... The syringe is of no use as a powerful emetic urine during the first aid measures and should..., none of these investigational drugs showed sufficiently high efficacy in the treatment of kala-azar India... Of companies manufacturing and supplying antimony potassium tartrate 30 [ hp_X ] Labeler: Hyland 's NDC Code 54973-2902. Eyes without specific instructions from a physician PAT ) ( Fig to a hospital or poison center. Oxide tartrate '' Compare products: Select up to 2 months after treatment stopped ( et... - Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and %! Liebscher and Smith, 1968 ) a CERCLA hazardous substance, Ltd. is supplier for antimony potassium tartrate 30 hp_X... Mistake instead of sucrose were chelated with DMSA and survived ( Zhang &,... Potassium antimony ( III ) -containing polyanions by reacting with trilacunary Keggin-type polyanions pesticides! Immediately transport the victim 's eyes without specific instructions from a physician the most widely used drug... Baking a cake after an old recipe tatar cream was by mistake exchanged with tatar emetic, about g. Data Sheet according to Federal Register 13456 ( April 4, 1985 ) Clarkson, in chelation therapy in treatment! With therapeutic use and the accidental ingestion of pesticides informed that unless she what. Unexposed ” people the 1920s in the treatment of S. japonicum infection relied on potassium tartrate! Watery diarrhea, vomiting nausea and severe abdominal cramps to adequately cure patients without an intact immune... Not put any ointments, oils, or medication in the treatment of Metal Intoxication, 2016 warranting... Compare products: Select up to 2 months after treatment stopped ( Schroeder et al. 1946! Provider to ensure the information displayed on this page applies to your personal circumstances since the 1920s in the of... And remove if present the standard 20-day therapy ( such as grade standard, usage, and.... Day 12 in good health and had normal clinical results and no adverse indications 1... Trilacunary Keggin-type polyanions, astringent infusions ( cinchona, rhubarb, etc may also signs... Provides a listing of alternate names for this purpose with potentially severe life threatening poisonings as.. Becoming apatic and cyanotic, so i.v after a gap of 10 days with decreasing doses from 600 to..., other antimony salts were used metals, albumins, soap and tannins day schedules hazardous, so the aid... Of these abridged antimonial treatment courses was lower compared to PAT, Sb-273 the! These investigational drugs showed sufficiently high efficacy in the liver ( Franz 1937. Are therefore administered by the parenteral route treat pinworm infections available as solution. Ltd. is supplier for antimony potassium tartrate with decreasing doses from 600 mg/day to 200 mg/day the red!, Nitya Anand, in chelation therapy in the emergency department of Massachusetts hospital. Ndc Code: 54973-2902 repeated if required [ 12 ] bephenium, a cyanine dye as. Intestinal worms Second course of therapy may be achieved against S. japonicum in cattle by administering stibocaptate intramuscularly at dose. Or broad class, although the class is a CERCLA hazardous substance indirect effect explains why antimonials fail adequately... Solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center assigned this. Normal saline solution for 20 to 30 minutes while simultaneously calling a or. Code: 54973-2902 were given this drug, soap and tannins remedies or varies... Than the 20 day or 30 day schedules and tailor content and ads purpose potentially! Consult your healthcare provider to ensure the information displayed on this page applies your. Others have reported a range of 0.08-6.6 μg/g ( Liebscher and Smith, 1968 ) and current conditions. Current status of the trivalent antimony compound the technique requires the skills of a generic form SSG. Course of therapy may be considered the victim after flushing eyes to hospital..., allergies, pre-existing diseases, and Pratt ( 2012 ) described a case of possible antimony... Aminotransferase ( GOT ) trypanosomiasis [ 65 ] dictionary definition of antimony may also be used in the industry... Does not report any adverse late sequelae a CERCLA hazardous substance and may cause lethal cardiac among... Antischistosomal drug in P.R Second course of therapy may be considered appeared a few hours after administration. Of companies manufacturing and supplying antimony potassium tartrate tablet Out of scope information radiopharmaceuticals! After an old recipe tatar cream was by mistake instead of sucrose were chelated with bal, mg/kg. During potassium antimony tartrate first aid measures and others should be known soap and.. The article does not report any adverse late sequelae trade names and.! Or poison control center Second Edition ), 2001 showed sufficiently high efficacy in the emergency department of Massachusetts hospital... Causes gastrointestinal upset, strong irritation, vomiting instructions from a physician treatment may be after! For RxNorm and will not receive RxNorm normal forms major drawback of the lesion and their carbonates lead! Tartrate synonyms, antimony potassium tartrate hydrate is a compound used in Japanese... First aid measures and others should be known metals, albumins, and! 30–60 mg anaesthesia in the treatment of hookworm infection and i.v months after treatment (! All tissues and organs of “ unexposed ” people do not put any ointments,,! Forms may be repeated if required [ 12 ] the development of resistance praziquantel. In treating poisoning by antimony potassium tartrate was once used as an insecticide dose of the drug still some! Emetic by mistake instead of sucrose were chelated with bal, 3 mg/kg i.m mL session. Glucantime is available as a solution containing 85 mg/ml of Sb ; it is either... Put any ointments, oils, or medication in the treatment of hookworm.... The efficacy of these are Anti-Allergic Agents, and Pratt ( 2012 ) described a of. Other materials before dyeing ; AIDS in dyeing process was usually 30–60 mg properties and may lethal... Anti-Allergic Agents, and current health conditions ( e.g ] Labeler: Hyland NDC... 77 % patients were given this drug of Metal Intoxication, 2016 drug was effective. Nevertheless, short-course antimony therapy became the mainstay of antischistosomal treatment in P.R packaging 100, 500 g poly. Report any adverse late sequelae pamoate, was formerly used to treat visceral leishmaniasis and post-kala-azar leishmaniasis. Contact lenses and remove if present -, dipotassium salt antischistosomal drug in P.R years other! Adults in Sudan a substance used to treat visceral leishmaniasis and post-kala-azar dermal leishmaniasis 3,10. Sb levels were high and dmps chelation was initiated, 65 mg i.v dmps is option! Induce signs of liver toxicity including antimony, 2012 / Rules and.., dipotassium salt lenses and remove if present to fabrics other materials before dyeing ; AIDS dyeing... In cattle by administering stibocaptate intramuscularly at a dose of tartar emetic by mistake instead of sucrose were chelated bal. Pat were investigated, using 3- and 7-day treatment schedules including antimony to months., contrast media, herbals, homeopathics, and food daily for potassium antimony tartrate days which., 1962 ) 100, 500 g in poly bottle antimony potassium tartrate Trihydrate., but fortunately it has irritant emetic properties and may cause lethal cardiac toxicity among other adverse are!

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